期刊
EUROPEAN JOURNAL OF EPIDEMIOLOGY
卷 30, 期 12, 页码 1263-1275出版社
SPRINGER
DOI: 10.1007/s10654-015-0091-9
关键词
Leukaemia; Lymphoma; Traffic exhaust; Air pollution; Tumours of the central nervous system; Vehicle emissions
资金
- Swiss Federal Office of Public Health [08.001616, 10.002946, 12.008357]
- Swiss Cancer League [02224-03-2008]
- Swiss Cancer Research [3049-08-2012, 3515-08-2014]
- Swiss National Science Foundation fellowship [PZ00P3_147987]
- Swiss Paediatric Oncology Group
- Schweizerische Konferenz der kantonalen Gesundheitsdirektorinnen und -direktoren
- Swiss Cancer Research
- Kinderkrebshilfe Schweiz
- Ernst-Gohner Stiftung
- Stiftung Domarena
- National Institute of Cancer Epidemiology and Registration
Children living near highways are exposed to higher concentrations of traffic-related carcinogenic pollutants. Several studies reported an increased risk of childhood cancer associated with traffic exposure, but the published evidence is inconclusive. We investigated whether cancer risk is associated with proximity of residence to highways in a nation-wide cohort study including all children aged < 16 years from Swiss national censuses in 1990 and 2000. Cancer incidence was investigated in time to event analyses (1990-2008) using Cox proportional hazards models and incidence density analyses (1985-2008) using Poisson regression. Adjustments were made for socio-economic factors, ionising background radiation and electromagnetic fields. In time to event analysis based on 532 cases the adjusted hazard ratio for leukaemia comparing children living < 100 m from a highway with unexposed children (a parts per thousand yen500 m) was 1.43 (95 % CI 0.79, 2.61). Results were similar in incidence density analysis including 1367 leukaemia cases (incidence rate ratio (IRR) 1.57; 95 % CI 1.09, 2.25). Associations were similar for acute lymphoblastic leukaemia (IRR 1.64; 95 % CI 1.10, 2.43) and stronger for leukaemia in children aged < 5 years (IRR 1.92; 95 % CI 1.22, 3.04). Little evidence of association was found for other tumours. Our study suggests that young children living close to highways are at increased risk of developing leukaemia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据