期刊
CANCER DISCOVERY
卷 7, 期 11, 页码 1218-1220出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-17-0996
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资金
- NIH [RO1 CA150925, RO1 CA190170, R21 CA197887, T32 CA190216]
Lysosomes are the recycling centers of the cell where organelles and proteins are degraded during autophagy and macropinocytosis; they also serve as signaling hubs that control the activity of mTORC1. In this issue, Rebecca and colleagues report the development of a new type of lysosomal inhibitor for cancer therapy that can inhibit multiple lysosomal activities that are needed for tumor cell survival and growth. (C) 2017 AACR.
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