期刊
CYTOKINE
卷 96, 期 -, 页码 132-137出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2017.04.002
关键词
IL-18; EV71; Inflammasome; Cytokine
资金
- Natural Science Foundation of China [31570895, 91429307, 31370892, 31600146, 81560339]
- National Key Basic Research Programs [2015CB554302, 2014CB541905]
- Shanghai Sailing Program [16YF1412400]
- Shanghai Natural Science Foundation [16ZR1439900]
- China Postdoctoral Science Foundation [2016M601659]
- International Partnership Program of the Chinese Academy of Sciences [153831KYSB20160009]
- TOTAL foundation for HFMD
Previous study has demonstrated that the NLRP3 inflammasome is essential for protecting murine host against Enterovirus 71 (EV71) infection. However, the underlying mechanism remained unknown. Here we discovered that the pleiotropic cytokine interleukin-18 (IL-18), an NLRP3 inflammasome-dependent effector protein, exhibits a protective capability against EV71 challenge. Deficiency of IL-18 in mice exacerbated EV71 infection, which was reflected by increased viral replication, elevated production of interferons (IFN-beta, IFN-gamma), proinflammatory cytokines (TNF-alpha, IL-6) and chemokine CCL2, as well as decreased survival of experimental animals. Conversely, administration of recombinant IL-18 considerably restrained EV71 infection in IL-18 deficient mice. Thus, our results revealed a protective role for IL-18 against EV71 challenge, and indicated a novel therapeutic application for IL-18 in EV71 associated hand, foot, and mouth disease (HFMD).
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