期刊
BIOLOGICAL CHEMISTRY
卷 398, 期 8, 页码 919-927出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2017-0113
关键词
DNA damage response; DNA replication; HPV; human papillomavirus; partitioning; recombination dependent replication
资金
- Intramural Research Program of the NIAID, NIH [ZIA AI001073]
Animal and human papillomaviruses (HPVs) replicate persistently in specific types of stratified epithelia of their host. After the initial infection, the viral genome replicates at low levels in the dividing cells of the epithelium, and these cells form a reservoir of infection that can last for decades. When the infected cells differentiate, viral genomes replicate to high levels to form progeny virus that is released from the surface of the epithelium. This complex life cycle requires several different modes of viral DNA replication, but papillomaviruses are masters at hijacking key cellular processes to facilitate their own reproduction.
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