期刊
DRUG DISCOVERY TODAY
卷 22, 期 8, 页码 1224-1232出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2017.05.006
关键词
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资金
- Chettinad Academy of Research and Education, Chennai
- IIT-Madras, India
Despite advances in treatment modalities, colon cancer (CC) is the third most common cause of cancer related death worldwide. Subsequent unfavorable effects owing to toxicity of conventional drugs are a challenging problem associated with chemotherapy. There is noticeable concern toward site-specific/targeted delivery of chemotherapeutic drugs specifically to the affected site of the colon in a predictable and reproducible manner. However, the biggest challenge in successful drug targeting for the colon is avoidance of drug absorption and/or degradation in the upper gastrointestinal tract before the drug reaches the colon. Nanoparticles endowed with targeting abilities offer a novel approach for site-specific delivery of chemotherapeutic agents. The present review focuses on recent approaches for colon-specific drug delivery (CDDS) and aims to unveil the emerging possibilities and advances in the treatment of CC with CDDS.
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