期刊
CHEMICAL BIOLOGY & DRUG DESIGN
卷 90, 期 2, 页码 167-174出版社
WILEY
DOI: 10.1111/cbdd.12948
关键词
fluorescent probe; hydrogen sulfide; mitochondria targeting; selectively
资金
- National Science and Technology Major Project of the Ministry of Science and Technology of China [2009ZX09102-033]
- National Natural Science Foundation of China [81273376, 81673299]
- Natural Science Foundation of Jiangsu Province [BK20131398]
A novel mitochondria-targeting fluorescent probe compound S-N-3 for hydrogen sulfide (H2S) in living cells has been designed and synthesized in this study. This article contained the chemosynthesis and some studies on bioactivity of the target compound in living cells. Compound S-N-3 is easy to synthesize and can remain stable under the effect of pH, system and photostability. In addition, it shows low cytotoxicity in cell imaging. And it can react with H2S highly selective in PBS or FBS solution, which would cause the obvious increase in fluorescence intensity. Therefore, the low-cost detection method for H2S is allowed for monitoring the quantity of H2S existed in the mitochondria.
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