期刊
DEVELOPMENT
卷 144, 期 15, 页码 2737-2747出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.144089
关键词
BMP signaling; Postnatal muscle growth; Satellite cells; Muscle stem cells; Mouse
资金
- Association Francaise contre les Myopathies (AFM)
- Agence Nationale de la Recherche (ANR) [ANR-12-BSV10038, ANR-16-CE14-0002-01, ANR-13-BSV1-0011]
- National Institutes of Health-National Institute of Arthritis and Musculoskeletal and Skin Diseases [R01 AR057344]
- Deutsche Forschungsgemeinschaft (DFG) (as part of the MyoGrad International Graduate School for Myology) [GK 1631/1]
- Fondation pour la Recherche Me'dicale (FRM) [FDT20140930879]
- Ministere de l'Enseignement Superieur et de la Recherche
- Universite' Franco-allemande (UFA, as part of the MyoGrad International Graduate School for Myology) [CDFA-06-11]
- Agence Nationale de la Recherche (ANR) [ANR-13-BSV1-0011] Funding Source: Agence Nationale de la Recherche (ANR)
Postnatal growth of skeletal muscle largely depends on the expansion and differentiation of resident stem cells, the so-called satellite cells. Here, we demonstrate that postnatal satellite cells express components of the bone morphogenetic protein (BMP) signaling machinery. Overexpression of noggin in postnatal mice (to antagonize BMP ligands), satellite cell-specific knockout of Alk3 (the gene encoding the BMP transmembrane receptor) or overexpression of inhibitory SMAD6 decreased satellite cell proliferation and accretion during myofiber growth, and ultimately retarded muscle growth. Moreover, reduced BMP signaling diminished the adult satellite cell pool. Abrogation of BMP signaling in satellite cell-derived primary myoblasts strongly diminished cell proliferation and upregulated the expression of cell cycle inhibitors p21 and p57. In conclusion, these results show that BMP signaling defines postnatal muscle development by regulating satellite cell-dependent myofiber growth and the generation of the adult muscle stem cell pool.
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