期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 74, 期 15, 页码 2723-2733出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-017-2492-2
关键词
GPR120; Fatty acids; White adipose tissue; Brown adipose tissue; Adipogenesis; Glucose uptake; Metabolic homeostasis
资金
- National Natural Science Foundation of China [31472075, 31402085]
- Hubei Provincial Creative Team Project of Agricultural Science and Technology [2007-620]
- Key Technology Research and Development Program of Hubei Province [2014ABB014, 2014ABC012]
It is well known that adipose tissue has a critical role in the development of obesity and metabolic diseases and that adipose tissue acts as an endocrine organ to regulate lipid and glucose metabolism. Accumulating in the adipose tissue, fatty acids serve as a primary source of essential nutrients and act on intracellular and cell surface receptors to regulate biological events. G protein-coupled receptor 120 (GPR120) represents a promising target for the treatment of obesity-related metabolic disorders for its involvement in the regulation of adipogenesis, inflammation, glucose uptake, and insulin resistance. In this review, we summarize recent studies and advances regarding the systemic role of GPR120 in adipose tissue, including both white and brown adipocytes. We offer a new perspective by comparing the different roles in a variety of homeostatic processes from adipogenic development to adipocyte metabolism, and we also discuss the effects of natural and synthetic agonists that may be potential agents for the treatment of metabolic diseases.
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