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William D. Bradley et al.
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Jie Bai et al.
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Joni Van der Meulen et al.
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Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma
Sarah K. Knutson et al.
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Anne Benard et al.
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Xuan Wang et al.
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Charlotte Pawlyn et al.
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Jun Li et al.
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Relja Popovic et al.
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Kyle D. Konze et al.
ACS CHEMICAL BIOLOGY (2013)
EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation
Wendy Beguelin et al.
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NSD2 Is Recruited through Its PHD Domain to Oncogenic Gene Loci to Drive Multiple Myeloma
Zheng Huang et al.
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Long-term Follow-up of MRC Myeloma IX Trial: Survival Outcomes with Bisphosphonate and Thalidomide Treatment
Gareth J. Morgan et al.
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A TC classification-based predictor for multiple myeloma using multiplexed real-time quantitative PCR
M. F. Kaiser et al.
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Transcriptional regulation by Polycomb group proteins
Luciano Di Croce et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
MMSET is the key molecular target in t(4;14) myeloma
F. Mirabella et al.
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Effects of induction and maintenance plus long-term bisphosphonates on bone disease in patients with multiple myeloma: the Medical Research Council Myeloma IX Trial
Gareth J. Morgan et al.
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Cyclophosphamide, thalidomide, and dexamethasone as induction therapy for newly diagnosed multiple myeloma patients destined for autologous stem-cell transplantation: MRC Myeloma IX randomized trial results
Gareth J. Morgan et al.
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A novel prognostic model in myeloma based on co-segregating adverse FISH lesions and the ISS: analysis of patients treated in the MRC Myeloma IX trial
K. D. Boyd et al.
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Kexin Xu et al.
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Brian A. Walker et al.
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Kevin D. Boyd et al.
CLINICAL CANCER RESEARCH (2011)
Proliferation is a central independent prognostic factor and target for personalized and risk-adapted treatment in multiple myeloma
Dirk Hose et al.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2011)
EZH2-Dependent Suppression of a Cellular Senescence Phenotype in Melanoma Cells by Inhibition of p21/CDKN1A Expression
Tao Fan et al.
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NSD2 Links Dimethylation of Histone H3 at Lysine 36 to Oncogenic Programming
Alex J. Kuo et al.
MOLECULAR CELL (2011)
The Polycomb complex PRC2 and its mark in life
Raphael Margueron et al.
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Total Therapy 3 for multiple myeloma: prognostic implications of cumulative dosing and premature discontinuation of VTD maintenance components, bortezomib, thalidomide, and dexamethasone, relevant to all phases of therapy
Frits van Rhee et al.
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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
Ryan D. Morin et al.
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Polycomb Target Genes Are Silenced in Multiple Myeloma
Antonia Kalushkova et al.
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Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells
Warren Fiskus et al.
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MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells
Jose L. R. Brito et al.
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Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
Gijs van Haaften et al.
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p21 in cancer: intricate networks and multiple activities
Tarek Abbas et al.
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Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases
SunHwa Hong et al.
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A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1
John D. Shaughnessy et al.
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RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins
Shu Xiao et al.
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Fenghuang Zhan et al.
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Thalidomide and hematopoietic-cell transplantation for multiple myeloma
B Barlogie et al.
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The Polycomb group protein EZH2 directly controls DNA methylation
E Viré et al.
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EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
IM Bachmann et al.
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The polycomb group protein enhancer of zeste homolog 2 (EZH2) is an oncogene that influences myeloma cell growth and the mutant ras phenotype
PA Croonquist et al.
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Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma
PL Bergsagel et al.
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EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
CG Kleer et al.
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