期刊
CARBOHYDRATE POLYMERS
卷 169, 期 -, 页码 441-450出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.04.027
关键词
Chitosan derivatives; Staphylococcus aureus; Bacillus cereus; Escherichia coli; Pseudomonas aeruginosa
资金
- [VEGA2/0065/15]
Cinnamaldehyde was immobilized to O-amine functionalized chitosan via a coupling reaction. Fourier transform infrared spectroscopy confirmed N-cinnamyl substitution. Wetting analyses demonstrate more hydrophobicity in the N-cinnamyl substituted O-amine functionalized chitosan compared to chitosan or unsubstituted O-amine functionalized chitosan. Thermal gravimetric analysis and differential scanning calorimetry demonstrates that the prepared N-cinnamyl substituted O-amine functionalized chitosan exhibits higher thermostability than unmodified chitosan at temperatures in which polysaccharides are commonly stored and utilised. The N-cinnamyl substituted O-amine functionalized chitosan, against four different bacteria strains [two gram-positive (Staphylococcus aureus and Bacillus cereus) and two gram -negative (Escherichia coli and Pseudomonas aeruginosa)], displays promotion of inhibition activity against these bacterial strains. Finally, the antioxidative activity of the N-cinnamyl substituted O-amine functionalized chitosan was compared with those activities of chitosan and O-amine functionalized chitosan. This was evaluated by uninhibited and inhibited hyaluronan degradation and ABTS assay. The N-cinnamyl substituted O-amine functionalized chitosan shows a lower activity towards donating a hydrogen radical compared to chitosan or O-amine functionalized chitosan. On the other hand, the Ncinnamyl substituted O-amine functionalized chitosan exhibited a higher ability to scavenge the ABTS' cation radical compared to chitosan and O-amine functionalized chitosan. (C) 2017 Elsevier Ltd. All rights reserved.
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