期刊
EMBO JOURNAL
卷 36, 期 15, 页码 2187-2203出版社
WILEY
DOI: 10.15252/embj.201696150
关键词
cancer; cardiovascular disease; endothelial cell; hypoxia; metabolism
资金
- FWO
- Marie Sklodowska-Curie Postdoctoral Fellowships
- Flemish Government [IUAP P7/03]
- FWO [G.0598.12, G.0532.10, G.0817.11, G.0834.13, 1.5.202.10.N, G0B1116N]
- Leducq Transatlantic Network Artemis
- AXA Research Fund [1465]
- Foundation against Cancer
- ERC [EU-ERC269073]
In contrast to the general belief, endothelial cell (EC) metabolism has recently been identified as a driver rather than a bystander effect of angiogenesis in health and disease. Indeed, different EC subtypes present with distinct metabolic properties, which determine their function in angiogenesis upon growth factor stimulation. One of the main stimulators of angiogenesis is hypoxia, frequently observed in disease settings such as cancer and atherosclerosis. It has long been established that hypoxic signalling and metabolism changes are highly interlinked. In this review, we will provide an overview of the literature and recent findings on hypoxia-driven EC function and metabolism in health and disease. We summarize evidence on metabolic crosstalk between different hypoxic cell types with ECs and suggest new metabolic targets.
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