期刊
CELL METABOLISM
卷 26, 期 2, 页码 301-309出版社
CELL PRESS
DOI: 10.1016/j.cmet.2017.07.001
关键词
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资金
- NIH [R01 CA103866, AI47389, T32 GM007753, F30 CA189333]
- Department of Defense [W81XWH-15-1-0230]
The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that responds to a diverse set of environmental inputs, including amino acids. Over the past 10 years, a number of proteins have been identified that help transmit amino acid availability to mTORC1. However, amino acid sensors for this pathway have only recently been discovered. Here, we review these recent advances and highlight the variety of unexplored questions that emerge from the identification of these sensors.
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