期刊
BIOMEDICAL OPTICS EXPRESS
卷 8, 期 11, 页码 5098-5112出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.8.005098
关键词
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资金
- Research to Prevent Blindness Stein Innovation Award
- National Institutes of Health (NIH) [U01EY025477, R01EY025231]
- Foundation Fighting Blindness
- F. M. Kirby Foundation
- Paul and Evanina Mackall Foundation Trust
- Glaucoma Research Foundation Catalyst for a Cure Initiative
Vision begins when light isomerizes the photopigments within photoreceptors. Noninvasive cellular-scale observation of the structure of the human photoreceptor mosaic is made possible through the use of adaptive optics (AO) enhanced ophthalmoscopes, but establishing noninvasive objective measures of photoreceptor function on a similar scale has been more difficult. AO ophthalmoscope images acquired with near-infrared light show that individual cone photoreceptor reflectance can change in response to a visible stimulus. Here we show that the intrinsic response depends on stimulus wavelength and intensity, and that its action spectrum is well-matched to the spectral sensitivity of cone-mediated vision. Our results demonstrate that the cone reflectance response is mediated by photoisomerization, thus making it a direct measure of photoreceptor function. (C) 2017 Optical Society of America.
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