期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1863, 期 8, 页码 2056-2063出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2016.11.008
关键词
Alternative splicing; Sarcomeric genes; Splicing factor; Heart failure
资金
- National Institute of General Medical Sciences [1003088F]
- American Heart Association (AHA) [1003018]
- Agricultural Experiment Station's competitive Grant from USDA/NIFA [1003093K]
Pre-mRNA splicing is an important biological process that allows production of multiple proteins from a single gene in the genome, and mainly contributes to protein diversity in eulcaryotic organisms. Alternative splicing is commonly governed by RNA binding proteins to meet the ever-changing demands of the cell. However, the mis-splicing may lead to human diseases. In the heart of human, mis-regulation of alternative splicing has been associated with heart failure. In this short review, we focus on alternative splicing of sarcomeric genes and review mis-splicing related heart failure with relatively well studied Sarcomeric genes and splicing mechanisms with identified regulatory factors. The perspective of alternative splicing based therapeutic strategies in heart failure has also been discussed. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据