期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 12, 期 14, 页码 1692-1699出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201700463
关键词
cancer; cytotoxicity; diabetes; speciation; vanadium
资金
- Australian Research Council (ARC) [DP0984722, DP1095310, DP130103566, DP140100176, DP160104172]
- Australian Research Council [DP1095310] Funding Source: Australian Research Council
Diverse biological activities of vanadium(V) drugs mainly arise from their abilities to inhibit phosphatase enzymes and to alter cell signaling. Initial interest focused on anti-diabetic activities but has shifted to anti-cancer and anti-parasitic drugs. V-based anti-diabetics are pro-drugs that release active components (e.g., H2VO4-) in biological media. By contrast, V anti-cancer drugs are generally assumed to enter cells intact; however, speciation studies indicate that nearly all drugs are likely to react in cell culture media during in vitro assays and the same would apply in vivo. The biological activities are due to V-V and/or V-IV reaction products with cell culture media, or the release of ligands (e.g., aromatic diimines, 8-hydroxyquinolines or thiosemicarbazones) that bind to essential metal ions in the media. Careful consideration of the stability and speciation of V complexes in cell culture media and in biological fluids is essential to design targeted V-based anti-cancer therapies.
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