期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 74, 期 16, 页码 2875-2897出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-017-2503-3
关键词
Gene expression; Splicing; Polyadenylation; Cell nucleus; Nucleocytoplasmic export; Export receptors; mRNA; Pre-mRNA processing; mRNP assembly; Nuclear pore complex
资金
- Swedish Research Council
Expression of protein-coding genes in eukaryotes relies on the coordinated action of many sophisticated molecular machineries. Transcription produces precursor mRNAs (pre-mRNAs) and the active gene provides an environment in which the pre-mRNAs are processed, folded, and assembled into RNA-protein (RNP) complexes. The dynamic pre-mRNPs incorporate the growing transcript, proteins, and the processing machineries, as well as the specific protein marks left after processing that are essential for export and the cytoplasmic fate of the mRNPs. After release from the gene, the mRNPs move by diffusion within the interchromatin compartment, making up pools of mRNPs. Here, splicing and polyadenylation can be completed and the mRNPs recruit the major export receptor NXF1. Export competent mRNPs interact with the nuclear pore complex, leading to export, concomitant with compositional and conformational changes of the mRNPs. We summarize the integrated nuclear processes involved in the formation and export of mRNPs.
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