期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 61, 期 8, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02540-16
关键词
colistin; Escherichia coli; KPC-28; KPC-3; OXA-48; antibiotic resistance; beta-lactamases; carbapenemase; mcr-1
资金
- National Institute for Agronomic Research (INRA) [USC-2018]
- Centre Hospitalier Universitaire de Clermont-Ferrand
- Sante Publique France
The spread of mcr-1-encoding plasmids into carbapenem-resistant Enterobacteriaceae raises concerns about the emergence of untreatable bacteria. We report the acquisition of mcr-1 in a carbapenem-resistant Escherichia coli strain after a 3-week course of colistin in a patient repatriated to France from Portugal. Whole-genome sequencing revealed that the Klebsiella pneumoniae carbapenemase-producing E. coli strain acquired two plasmids, an IncL OXA-48-encoding plasmid and an IncX4 mcr-1-encoding plasmid. This is the first report of mcr-1 in carbapenemase-encoding bacteria in France.
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