Synthesis of PAMAM dendrimers with porphyrin core and functionalized periphery as templates of metal composite materials and their toxicity evaluation

Experiments were performed for the synthesis of meso-substituted tetraphenyl porphyrins in order to obtain growth active points for PAMAM branches and a functionalized periphery with thiazole groups for increasing the metal complexation activity. Characterization by H-1 and C-13 NMR, mass spectrometry and infrared spectrometry confirmed the produced dendrimeric nanostructures; the chemical reduction of metallic Ag and Cu inside the dendrimer was proved by XPS. Finally, the toxicity of the metal-dendrimer complex was analyzed by means of the bacterial respiration test. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.