期刊
ARABIAN JOURNAL OF CHEMISTRY
卷 10, 期 -, 页码 S1254-S1266出版社
ELSEVIER
DOI: 10.1016/j.arabjc.2013.03.006
关键词
2,5-dimethyl-3-thienyl chalcones; Synthesis; IR and NMR spectra; Correlation analysis; Antimicrobial activities
Twelve 2,5-dimethyl-3-thienyl chalcones [E-1-(2,5-dimethyl-3-thienyl)-3-(substituted phenyl)-2-propen-1-ones] have been synthesized by Claisen-Schmidt condensation of 3-acetyl-2,5-dimethyl furon and substituted benzaldehydes. Yields of the chalcones are more than 80%. These chalcones were characterized by their physical constants and spectral data. The group frequencies of infrared nu(cm(-1)) of CO s-cis and s-trans, CH in-plane and out of plane, CH=CH out of plane, > C=C < out of plane modes, NMR chemical shifts delta(ppm) of H-alpha, H-beta, CO, C-alpha and C-beta of these chalcones were correlated with Hammett substituent constants, F and R parameters using single and multi-regression analyses. From the results of statistical analyses, the effects of substituents on the group frequencies are explained. Antibacterial, antifungal, antioxidant and insect antifeedant activities of these chalcones have been studied. (C) 2013 Production and hosting by Elsevier B.V.
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