期刊
INFECTION AND IMMUNITY
卷 85, 期 8, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.00101-17
关键词
microbiota; parasite; host pathogen; protozoa
资金
- NIH [AI-26649]
- Gates Foundation [OPP1173478]
- Bill and Melinda Gates Foundation [OPP1173478] Funding Source: Bill and Melinda Gates Foundation
Parasitic protozoan infections represent a major health burden in the developing world and contribute significantly to morbidity and mortality. These infections are often associated with considerable variability in clinical presentation. An emerging body of work suggests that the intestinal microbiota may help to explain some of these differences in disease expression. The objective of this minireview is to synthesize recent progress in this rapidly advancing field. Studies of humans and animals and in vitro studies of the contribution of the intestinal microbiota to infectious disease are discussed. We hope to provide an understanding of the humanprotozoal pathogen-microbiome interaction and to speculate on how that might be leveraged for treatment.
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