期刊
DRUG AND ALCOHOL DEPENDENCE
卷 177, 期 -, 页码 39-47出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2017.03.018
关键词
Executive functions; Alcohol-dependence; Shifting; Updating; Inhibition
资金
- Belgian Fund for Scientific Research (F.R.S.-FNRS, Belgium)
- Fonds de Recherche Clinique from the Universite catholique de Louvain
- Fondation pour la Recherche en Alcoologie (FRA, France)
Background: Alcohol-dependence is related to large-scale cognitive impairments, particularly for executive functions (EF). These deficits persist even after long-term abstinence and have a major impact on patients' everyday life and relapse risk. Earlier studies, based on multi-determined tasks, mostly focused on inhibition and did not offer a theoretically-grounded and exhaustive view of the differential deficit across EF. The present paper proposes a model-based exploration of EF in alcohol-dependent individuals (ALC), to precisely compare the specific deficit related to each executive subcomponent. Methods: Forty-seven recently detoxified ALC were compared to 47 matched healthy participants on a nine-tasks validated neuropsychological battery, simultaneously exploring and comparing the three main executive subcomponents (shifting, updating, and inhibition). Psychopathological comorbidities were also controlled for. Results: Reaction time indexes revealed a global slowing down among ALC, whatever the EF explored. Accuracy indexes revealed a moderate deficit for inhibition tasks but a massive impairment for shifting and updating ones. Complementary analyses indicated that the executive deficits observed were centrally related to alcohol dependence, while comorbid depressive symptoms appeared to intensify the deficits observed. Conclusions: By offering a direct comparison between the three major EF, these results showed that alcohol related executive deficits extend beyond the classically described inhibition impairment. This impairment encompasses each EF subcomponent, as ALC actually presented stronger deficits for updating and shifting abilities. This first observation of a multifaceted EF deficit stresses the need for an individualized evaluation and rehabilitation of EF during and/or after the detoxification process.
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