期刊
ARABIAN JOURNAL OF CHEMISTRY
卷 10, 期 -, 页码 S2890-S2895出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.arabjc.2013.11.018
关键词
Chalcones; Anti-bacterial activity; Chloramphenicol
Chalcone derivatives have been synthesized by the reaction of 3-acetyl-2,5-dimethylthiophene with corresponding active aldehyde in ethanolic NaOH in microwave oven. The structure of these compounds was established by elemental analysis, IR, H-1 NMR, C-13 NMR and EI-MS spectral analysis. The anti-bacterial activity of these compounds were first tested in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria, and then the minimum inhibitory concentration (MIC) was determined with the reference of standard drug Chloramphenicol. The results showed that compound 8 is a better inhibitor of both types of the bacteria (Gram-positive and Gram-negative) as compared to chloramphenicol. (C) 2014 Production and hosting by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据