A novel three component synthesis of 2-amino-4H-chromenes derivatives using nano ZnO catalyst

In this work, we attempted to synthesize organic soluble ZnO nano particles in the organic phase using zinc nitrate as a precursor. Also, ZnO nano particles have been characterized by XRD, SEM and TEM and then we report a simple and efficient method for the synthesis of 2-amino-4H-chromenes derivatives by aldehyde, malononitrile and dimedone by using ZnO nano-particles under reflux in ethanol (Scheme 1) the products are been characterized by CHN, GC/MS, IR and H-1 NMR spectroscopy. (C) 2012 Production and hosting by Elsevier B.V. on behalf of King Saud University.