期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 117, 期 -, 页码 178-195出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2017.07.008
关键词
Cocrystals; Mechanochemical grinding; Hot melt extrusion; Spray - drying; Antisolvent; Freeze - drying; Microfluidics; Ultrasound; Scale-up; Continuous
Pharmaceutical cocrystals are multicomponent systems composed of two or more molecules and held together by H-bonding. Currently, cocrystals provide exciting opportunities in the pharmaceutical industry for the development and manufacturing of new medicines by improving poor physical properties of Active Pharmaceutical Ingredients (APIs) such as processability, solubility, stability and bioavailability. According to the recent reclassification, cocrystals are considered as drug polymorph rather a new API which has a significant impact on drug development, regulatory submissions and intellectual property protection. This review summarizes recent trends and advances in synthesis, manufacturing and scale - up of cocrystals. The operational principles of several cocrystals manufacturing technologies are discussed including their advantages and disadvantages in terms of crystal quality, purity stability, throughput and limitations in large scale production. (C) 2017 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据