期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 78, 期 2, 页码 -出版社
WILEY
DOI: 10.1111/aji.12716
关键词
gestational diabetes; immune regulation; preeclampsia; pregnancy; recurrent miscarriage; vitamin D
资金
- Merck Serono China Research Fund for Fertility [0231519043]
- Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College [5001519002]
The well-established classic role of vitamin D is implicated in the regulation of the balance between calcium and phosphorus. Furthermore, vitamin D is also involved in many non-classic physiological processes, mainly including the regulation of cell proliferation, differentiation, apoptosis and immune function, participation in the inflammatory response and maintenance of genome stability function. During pregnancy, vitamin D receptor and its metabolic enzymes are expressed at the placenta and decidua, indicating the potential role in the mechanism of immunomodulation at the maternal-fetal interface. The insufficiency or deficiency of vitamin D may affect the mother directly and is related to specific pregnancy outcomes, such as preeclampsia, gestational diabetes, and recurrent miscarriage. This article reviews the effects of vitamin D on immune regulation during pregnancy.
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