期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 30, 页码 25098-25106出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b05824
关键词
black phosphorus quantum dots; bioimaging; photodynamic therapy; photothermal therapy; low cytotoxicity
资金
- National Natural Science Foundation of China [61335011, 61675072, 61275187, 21505047, 11404116]
- Natural Science Foundation of Guangdong Province of China [2014A030310306, S2013040016223, 2014A030311024]
- Science and Technology Project of Guangdong Province of China [2012A080203008, 2014A020212282]
- Science and Technology Innovation Project of the Education Department of Guangdong Province of China [2013KJCX0052]
A multifunctional nanoplatform based on black phosphorus quantum dots (BPQDs) was developed for cancer bioimaging and combined photothermal therapy (PTT) and photo dynamic therapy (PDT). BPQDs were functionalized with PEG chains to achieve improved biocompatibility and physiological stability. The as-prepared nanoparticles exhibite prominent near-infrared (NIR) photothermal and red-light-triggered photodynamic properties. The combined therapeutic application of PEGylated BPQDs were then performed in vitro and in vivo. The results demonstrate that the combined phototherapy significantly promote the therapeutic efficacy of cancer treatment in comparison with PTT or PDT alone. BPQDs could also serve as the loading platform for fluorescent molecules, allowing reliable imaging of cancer cells. In addition, the low cytotoxicity and negligible side effects to main organs were observed in toxicity experiments. The theranostic characteristics of PEGylated BPQDs provide an uplifting potential for the future clinical applications.
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