期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 30, 页码 25114-25127出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b06192
关键词
indocyanine green; gold nanoclusters; near-infrared fluorescence imaging; photoacoustic imaging; synchronous therapy; fluorescence resonance energy transfer; real-time monitoring
资金
- Major State Basic Research Development Program of China (973 Program) [2015CB755500]
- Natural Science Foundation of China [81571745, 81401521, 81327801]
- Science and Technology Innovation Fund of Shenzhen [JCYJ20150401145529015, JCYJ20160229200902680]
Well-designed gold nanoclusters-indocyanine green nanoprobes (Au NCs-INPs) have been developed by the conjugation of Au NC assemblies with indocyanine green (ICG) for the therapeutic real-time monitoring based on fluorescence resonance energy transfer (FRET). The synthesized Au NCs-INPs demonstrated the improved cellular uptake and effective tumor targeting because of the enhanced permeability and retention effect and the gp60-mediated secreted protein acidic and rich in cysteine combined transport pathway, suggesting excellent dual-modal near-infrared fluorescence and photoacoustic imaging. Moreover, the simultaneous photodynamic therapy (PDT) and photothermal therapy (PTT) of Au NCs-INPs exhibited higher cancer cell killing and tumor removal efficiency than those of PDT or PTT alone. More importantly, a promising therapeutic monitoring strategy was performed based on FRET between Au NCs and ICG, suggesting that Au NCs-INPs could be utilized to evaluate the therapeutic response by real-time monitoring the change in Au NCs in fluorescence intensity together with ICG supersession. Therefore, Au NCs-INPs as a novel photosensitizer have great potentials for combined tumor imaging, therapy, and therapeutic monitoring in real time.
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