4.3 Article

Pyoderma Gangrenosum: A Critical Appraisal

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ADVANCES IN SKIN & WOUND CARE
卷 30, 期 12, 页码 534-542

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LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.ASW.0000526605.34372.9e

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cutaneous disease; inflammatory bowel disease; neutrophilic dermatosis; pyoderma gangrenosum; ulcer

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Pyoderma gangrenosum (PG) is an uncommon cutaneous disease, presenting with recurrent painful ulcerations most commonly on the lower extremities. The diagnosis is made according to a typical presentation, skin lesion morphology, skin biopsy, histopathology, and the exclusion of other etiologies. Classically, PG presents with painful ulcers with well-defined violaceous borders; other variants including bullous, pustular, and vegetative/granulomatous can also occur. Treatment of PG involves a combination of topical and systemic anti-inflammatory and immunosuppressive medications, wound care, antimicrobial agents for secondary infections, and treatment of the underlying etiology. This article is a continuing education review of the literature with a focus on the clinical application of the pathophysiology, diagnosis, and treatment of this challenging disease.

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