期刊
EUROPEAN JOURNAL OF DERMATOLOGY
卷 27, 期 -, 页码 12-14出版社
JOHN LIBBEY EUROTEXT LTD
DOI: 10.1684/ejd.2017.3040
关键词
microRNA; skin wound healing; inflammation; proliferation; chronic wound
类别
资金
- Swedish Research Council (Vetenskapsradet) [2013-03085, 015-06246, 2016-02051]
- Ragnar Soderbergs Foundation [M31/15]
- Hedlunds Foundation
- Welander and Finsens Foundation (Hudfonden)
- Ake Wibergs Foundation
- Jeanssons Foundation
- Swedish Psoriasis Foundation
- Ming Wai Lau Centre for Reparative Medicine
- Tore Nilsons Foundation
- Lars Hiertas Foundation
- Karolinska Institutet
- Swedish Research Council [2016-02051, 2013-03085] Funding Source: Swedish Research Council
- Vinnova [2016-02051] Funding Source: Vinnova
Wound healing is a fundamental physiological progress to keep the integrity of the skin. The transition from inflammation to proliferation is a critical step during skin wound repair process. Impairment of this transition has been known as a common dominator in the pathophysiology of chronic non-healing wounds. MicroRNAs (miRNAs) are short non-coding RNAs regulating gene expression. Emerging evidence has revealed that miRNAs play important roles in both normal skin wound healing and in the pathogenesis of chronicwounds. We focus on the miRNAs regulating the inflammation-proliferation transition during wound healing and propose that these miRNAs may be promising targets for development of more effective wound therapy.
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