期刊
BRITISH JOURNAL OF NUTRITION
卷 117, 期 11, 页码 1570-1576出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114517001350
关键词
Magnesium; Fractures; Osteoporosis; Epidemiology
资金
- National Institutes of Health [N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262]
- Merck Research Laboratories
- Novartis Pharmaceuticals Corporation
- GlaxoSmithKline
- Pfizer, Inc.
Research considering the relationship between dietary Mg and osteoporosis as well as fractures are sparse and conflicting. We therefore aimed to investigate Mg intake and the onset of fractures in a large cohort of American men and women involved in the Osteoarthritis Initiative over a follow-up period of 8 years. Dietary Mg intake (including that derived from supplementation) was evaluated through a FFQ at baseline and categorised using sex-specific quintiles (Q); osteoporotic fractures were evaluated through self-reported history. Overall, 3765 participants (1577 men; 2071 women) with a mean age of 60.6 (sd 9.1) years were included. During follow-up, 560 individuals (198 men and 368 women) developed a new fracture. After adjusting for fourteen potential confounders at baseline and taking those with lower Mg intake as reference (Q1). men (hazard ratio (HR) 0.47; 95 % CI 0.21, 1.00, P = 0.05) and women (HR 0.38; 95 % CI 0.17, 0.82, P = 0.01) in the highest quintile reported a significantly lower risk for fracture. Women meeting the recommended Mg intake were at a 27 % decreased risk for future fractures. In conclusion, higher dietary Mg intake has a protective effect on future osteoporotic fractures, especially in women with a high risk for knee osteoarthritis. Those women meeting the recommended Mg intake appear to be at a lower risk for fractures.
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