期刊
CHEMBIOCHEM
卷 18, 期 14, 页码 1350-1363出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201700153
关键词
cyclic peptides; cyclotides; cystine knots; drug design; imaging agents
资金
- National Institutes of Health [R01-GM113363]
- Department of Defense Congressionally Directed Medical Research Programs in Lung Cancer [LC150051]
- BROAD Medical Research Program-Crohn's & Colitis Foundation of America [483566]
- Lupus Research Institute
- Whittier Foundation
- CDMRP [893440, LC150051] Funding Source: Federal RePORTER
Cyclotides are globular microproteins with a unique head-totail cyclized backbone, stabilized by three disulfide bonds forming a cystine knot. This unique circular backbone topology and knotted arrangement of three disulfide bonds makes them exceptionally stable to chemical, thermal, and biological degradation compared to other peptides of similar size. In addition, cyclotides have been shown to be highly tolerant to sequence variability, aside from the conserved residues forming the cystine knot. Cyclotides can also cross cellular membranes and are able to modulate intracellular protein-protein interactions, both in vitro and in vivo. All of these features make cyclotides highly promising as leads or frameworks for the design of peptide-based diagnostic and therapeutic tools. This article provides an overview on cyclotides and their applications as molecular imaging agents and peptide-based therapeutics.
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