4.5 Article

Toward Hyperpolarized 19F Molecular Imaging via Reversible Exchange with Parahydrogen

期刊

CHEMPHYSCHEM
卷 18, 期 15, 页码 1961-1965

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/cphc.201700594

关键词

fluorine-19; hyperpolarization; molecular imaging; MRI; parahydrogen

资金

  1. NSF [CHE-1058727, CHE-1363008, CHE-1416268, CHE-1416432]
  2. Direct For Mathematical & Physical Scien
  3. Division Of Chemistry [1416432, 1416268] Funding Source: National Science Foundation

向作者/读者索取更多资源

Fluorine-19 has high NMR detection sensitivity-similar to that of protons-owing to its large gyromagnetic ratio and high natural abundance (100 %). Unlike protons, however, fluorine-19 (F-19) has a negligible occurrence in biological objects, as well as a more sensitive chemical shift. As a result, in vivo F-19 NMR spectroscopy and MR imaging offer advantages of negligible background signal and sensitive reporting of the local molecular environment. Here we report on NMR hyperpolarization of 19F nuclei using reversible exchange reactions with parahydrogen gas as the source of nuclear spin order. NMR signals of 3-fluoropyridine were enhanced by approximate to 100 fold, corresponding to 0.3% F-19 nuclear spin polarization (at 9.4 T), using about 50% parahydrogen. While future optimization efforts will likely significantly increase the hyperpolarization levels, we already demonstrate the utility of F-19 hyperpolarization for high-resolution hyperpolarized F-19 imaging and hyperpolarized F-19 pH sensing.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据