期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 33, 页码 9886-9890出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201705530
关键词
aziridination; dirhodium catalysis; hydroxylamine-O-sulfonic acid; olefins; nitrenoids
资金
- Rice University
- National Institutes of Health [R01 GM-114609-01]
- National Science Foundation (CAREER) [SusChEM CHE-1546097]
- Robert A. Welch Foundation [C-1764]
- ACS-PRF [51707-DNI1]
- Amgen
- Biotage
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1546097] Funding Source: National Science Foundation
A Rh-II-catalyzed direct and stereospecific N-H- and N-alkyl aziridination of olefins is reported that uses hydroxylamine-O-sulfonic acids as inexpensive, readily available, and nitro group-free aminating reagents. Unactivated olefins, featuring a wide range of functional groups, are converted into the corresponding N-H or N-alkyl aziridines in good to excellent yields. This operationally simple, scalable transformation proceeds efficiently at ambient temperature and is tolerant towards oxygen and trace moisture.
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