期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 33, 页码 9736-9740出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201703145
关键词
artificial organelles; coacervates; liposomes; microfluidics; phase transitions
资金
- European Union's Horizon research and innovation programme under the Marie Sklodowska-Curie [659907]
- Netherlands Organization for Scientific Research (NWO) [718.014.001]
- Ministry of Education, Culture and Science [024.001.035]
- Marie Curie Actions (MSCA) [659907] Funding Source: Marie Curie Actions (MSCA)
Coacervates have been widely studied as model compartments in protocell research. Complex coacervates composed of disordered proteins and RNA have also been shown to play an important role in cellular processes. Herein, we report on a microfluidic strategy for constructing monodisperse coacervate droplets encapsulated within uniform unilamellar liposomes. These structures represent a bottomup approach to hierarchically structured protocells, as demonstrated by storage and release of DNA from the encapsulated coacervates as well as localized transcription.
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