期刊
DYES AND PIGMENTS
卷 145, 期 -, 页码 307-314出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2017.06.016
关键词
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资金
- Department of Chemistry at Georgia State University
- Georgia State University Brains and Behavior Seed Grant
- Atlanta Clinical and Translational Science Institute Healthcare Innovation Seed Grant
- Georgia Research Alliance Ventures Phase 1 Grant
- National Cancer Institutes of Health [U01 CA179671, R01 CA169127]
Cancer theranosis has materialized as a significant alternative to the separate diagnosis and treatment of cancer optimizing efficacy. Based on our previous work, it was determined that esterified heptamethine cyanine dyes were selectively cytotoxic to cancer cells. In order to determine the optimal N-alkyl chain length, a series of nine near-infrared fluorescent heptamethine cyanine dyes with monoester, diester, and diacid functional groups and differing chain lengths of three, six and ten carbons have been synthesized, isolated, and purified. They were characterized by H-1 NMR, C-13 NMR and mass spectrometry and their optical properties were measured. It was found that dyes with a 6 carbon N-indolenine substituent were the most selective for cancer theranosis in pancreatic cancer cell line S2-013. (C) 2017 Elsevier Ltd. All rights reserved.
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