期刊
ACS CATALYSIS
卷 7, 期 11, 页码 7917-7922出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.7b02667
关键词
asymmetric cooperative catalysis; trienamine; palladium; asymmetric allylation; furfural
资金
- NSFC [21232007, 21502183]
- Chinese Academy of Science [XDB20000000]
An asymmetric allylation reaction at the benzylic position of furfurals that are easily accessed from 5-HMF, which is a biomass derivative, has been established by palladium and amine cooperative catalysis. The high levels of enantioselectivity of up to 97% enantiometric excess (ee) were enabled by the synergistic stereochemical control of a chiral TADDOL-based phosphoramidite ligand and a chiral diphenylprolinol silyl ether. The product could be feasibly transformed to chiral aryl substituted spiroacetal via a four-step reaction sequence.
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