期刊
ACS CATALYSIS
卷 7, 期 9, 页码 5654-5660出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.7b01912
关键词
aerobic oxidation; alkynes; cross-coupling; asymmetric catalysis; cooperative catalysis
资金
- National Natural Science Foundation of China [21432006, 21625205, 21321061]
- National Program for Support of Top-notch Young Professionals
An efficient asymmetric aerobic oxidation of tetrahydroisoquinolines with terminal alkynes was realized under mild reaction conditions using O-2 as the sole oxidant. A chiral N,N'-dioxide/zinc(II)/iron(II) bimetallic cooperative catalytic system proves to be efficient for the formation of various alpha-alkynyl substituted tetrahydroisoquinolines in good to excellent yields and enantioselectivities. A primary mechanistic study supports an enantioselective electrophilic addition of zinc acetylide to the iminium intermediates, formed through a molecular O-2-involved oxidative process.
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