期刊
ACS CATALYSIS
卷 8, 期 1, 页码 258-271出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.7b03334
关键词
nitrile-containing alkyl radicals; C(sp(3))-H bond functionalization; oxidative coupling; tandem radical reaction; copper catalysis
资金
- Nanjing Tech University
- SICAM Fellowship from Jiangsu National Synergetic Innovation Center for Advanced Materials
- Nanyang Technological University
Chemoselective functionalizations of intrinsically less reactive C(sp(3))-H bonds of alkyl nitriles are of particular interest to the chemical community because these strategies provide opportunities for the introduction of important cyanoalkyl groups onto target frameworks in a step-economical fashion. In recent years, the introduction of nitrile-containing alkyl radicals in tandem radical additions and oxidative couplings has inarguably brought chemists a new radical reaction platform for the diverse synthesis of natural products and pharmaceuticals. Compared with the wide applications of various C-centered radicals adjacent to a heteroatom, however, nitrile-containing alkyl radicals remain largely unexplored. New methods for C(sp(3))-H bond oxidative functionalization of alkyl nitriles and new mechanistic manifolds would result in the development of a broad range of novel reactions. Therefore, this review will give an overview of various types of radical cyanoalkylation using the key alkyl nitrile reactants, which lie beyond traditional coupling chemistry.
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