期刊
ACS CATALYSIS
卷 7, 期 6, 页码 4057-4061出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.7b01133
关键词
photoredox catalysis; C-H functionalization; heterocycles; alkylation; Minisci reaction; decarboxylation
资金
- NRW Graduate School of Chemistry
- Deutsche Forschungsgemeinschaft
The direct visible light-mediated C-H alkylation of heteroarenes using aliphatic carboxylic acids is reported. This mild method proceeds at low catalyst loadings (0.5 mol %) and has a high functional group tolerance and a broad substrate scope. Notably, functionalization of (iso)quinoline, pyridine, phthalazine, benzothiazole, and other heterocyclic derivatives with both cyclic and acyclic primary, secondary, and tertiary carboxylic acids as well as amino and fatty acids proceeded under the standard conditions at room temperature. This protocol enables the rapid conversion of abundant feedstock materials into medically relevant drug-like moieties.
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