期刊
ACS CATALYSIS
卷 7, 期 12, 页码 8152-8158出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.7b02817
关键词
alcohols; nickel; borrowing-hydrogen catalysis; N-Alkylation; earth-abundant metal; amities
资金
- SERB of India [ECR/2015/000600]
- IIT-R
Herein, we developed an efficient and selective nickel catalyzed monoalkylation of various primary alcohols with aryl and heteroaryl amines together with diols and amino alcohol derivatives. Notably, the catalytic protocol consisting of an earth-abundant and non precious NiBr2/L1 system enables the transformations in the presence of hydroxyl, alkene, nitrile, and nitro functionalities. As a highlight, we have demonstrated the alkylation of diamine, intramolecular cyclization to N-heterocycles, and functionalization of complex vitamin E, an (+/-)-alpha-tocopherol derivative. Preliminary mechanistic studies revealed the participation of a benzylic C-H bond in the rate -determining step.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据