期刊
ACS CATALYSIS
卷 7, 期 4, 页码 2425-2429出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.7b00300
关键词
asymmetric catalysis; 1,1,2-triarylethanes; arylboration; cross-coupling; modular synthesis
资金
- NSFC [21472184, 21272226, 21572218, 21402186]
- Western-Light Foundation of CAS
An enantioselective Cu/Pd-catalyzed borylative coupling of styrenes with aryl/alkenyl iodides was realized using a chiral sulfoxide-phosphine (SOP) ligand. Enantioenriched 1,1-diarylethyl and beta-arylhomoallylic boronates are readily prepared. A streamlined procedure merging arylboration and subsequent Pd-catalyzed Suzuki-Miyaura cross-coupling enables the modular assembly of enantioenriched 1,1,2-triarylethanes, including two medicinally important chiral small-molecule targets.
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