期刊
ACS CATALYSIS
卷 7, 期 7, 页码 4441-4445出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.7b01123
关键词
Cu-catalyzed; tandem borylation
资金
- National Institutes of Health [R01GM116987, 3R01GM116987-01S1]
- University of North Carolina at Chapel Hill
Catalytic enantioselective synthesis of 1-hydroxy-2,3-bisboronate esters through multicomponent borylation/1,2-addition is reported. Catalyst and substrates are readily available, form both a C-B and C-C bond, and generate up to three contiguous stereocenters. The reaction is tolerant of aryl, vinyl, and alkyl aldehydes and ketones in up to 95% yield, >20:1 dr, and 99:1 er. Intramolecular additions to aldehydes and ketones result in stereodivergent processes. The hydroxy bis(boronate) ester products are amenable to site-selective chemical elaboration.
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