期刊
ACS CATALYSIS
卷 7, 期 4, 页码 2334-2338出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.6b03427
关键词
axial chirality; P,N-ligand; pi-stacking; asymmetric catalysis; A3 coupling
资金
- Higher Education Authority's PRTLI
- Irish Research Council (IRC) [GOIPD/2015/453]
A phosphino-imidazoline (PHIM) ligand possessing axial chirality is prepared in a straightforward five-step synthesis. Configurational stability around the chiral axis is achieved by the diastereofacial pi-stacking between the pentafluorophenyl and the naphthalene rings. In particular, access to enantiopure ligand (S,S,R-a)-2a was realized by fractional crystallization of the corresponding similar to 3:1 atropdiastereomeric mixture. The preliminary application of ligand (S,S,R-a)-UCD-PHIM showed excellent activities in the enantioselective copper-catalyzed A3 coupling (ee's up to 98.1% and yields up to 98%).
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