期刊
ACS CATALYSIS
卷 8, 期 1, 页码 59-62出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.7b03323
关键词
cascade reaction; self-assembly; peptides; copper; paraoxon
资金
- NIH [GM119634, P41GM103521]
- NSF [1332349]
- Alexander von Humboldt Foundation
Self-assembly of short de novo designed peptides gives rise to catalytic amyloids capable of facilitating multiple chemical transformations. We show that catalytic amyloids can efficiently hydrolyze paraoxon, which is a widely used, highly toxic organophosphate pesticide. Moreover, these robust and inexpensive metal-containing materials can be easily deposited on various surfaces, producing catalytic flow devices. Finally, functional promiscuity of catalytic amyloids promotes tandem hydrolysis/oxidation reactions. High efficiency discovered in a very small library of peptides suggests an enormous potential for further improvement of catalytic properties, both in terms of catalytic efficiency and substrate scope.
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