期刊
CELL HOST & MICROBE
卷 22, 期 2, 页码 232-245出版社
CELL PRESS
DOI: 10.1016/j.chom.2017.07.003
关键词
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资金
- National Health and Medical Research Council of Australia [637406]
- Victorian State Government OIS
- NHMRC IRIISS grants
- PATH/Malaria Vaccine Initiative (PATH/MVI) [07608-COL]
- U.S. Agency for International Development (USAID)
- NIH, USA [1R01HL139337]
Plasmodium species cause malaria by proliferating in human erythrocytes. Invasion of immunologically privileged erythrocytes provides a relatively protective niche as well as access to a rich source of nutrients. Plasmodium spp. target erythrocytes of different ages, but share a common mechanism of invasion. Specific engagement of erythrocyte receptors defines target cell tropism, activating downstream events and resulting in the physical penetration of the erythrocyte, powered by the parasite's actinomyosin-based motor. Here we review the latest in our understanding of the molecular composition of this highly complex and fascinating biological process.
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