期刊
NATURE COMMUNICATIONS
卷 8, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/ncomms15588
关键词
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资金
- USDA NIFA [2012-67013-19433]
- Cotton Inc [15-174]
- Texas AgriLife Research Cotton Improvement Program
- US National Science Foundation [IOS 1238189]
- Texas A&M University Graduate Diversity Fellowship
- USDA NIFA AFRI Pre-doctoral Fellowship [2017-67011-26060]
- [DGE-1144153]
- NIFA [2012-67013-19433, 578743] Funding Source: Federal RePORTER
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1258018] Funding Source: National Science Foundation
Transcription activator-like (TAL) effectors from Xanthomonas citri subsp. malvacearum (Xcm) are essential for bacterial blight of cotton (BBC). Here, by combining transcriptome profiling with TAL effector-binding element (EBE) prediction, we show that GhSWEET10, encoding a functional sucrose transporter, is induced by Avrb6, a TAL effector determining Xcm pathogenicity. Activation of GhSWEET10 by designer TAL effectors (dTALEs) restores virulence of Xcm avrb6 deletion strains, whereas silencing of GhSWEET10 compromises cotton susceptibility to infections. A BBC-resistant line carrying an unknown recessive b6 gene bears the same EBE as the susceptible line, but Avrb6-mediated induction of GhSWEET10 is reduced, suggesting a unique mechanism underlying b6-mediated resistance. We show via an extensive survey of GhSWEET transcriptional responsiveness to different Xcm field isolates that additional GhSWEETs may also be involved in BBC. These findings advance our understanding of the disease and resistance in cotton and may facilitate the development cotton with improved resistance to BBC.
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