期刊
NATURE COMMUNICATIONS
卷 8, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms15014
关键词
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资金
- National Institute of General Medical Sciences [R01GM105984]
- American Heart Association [14GRNT18880059]
- EMBO fellowship [ALTF 1082-2012]
- National Science Foundation [DMS-1219754]
- National Institutes of Health [R01 HD044750, R21 ES019259]
- National Science Foundation CAREER [IOS-0845775, CMMI-1100515]
- National Institutes of Health Biomechanics in Regenerative Medicine Training Grant [2T32EB003392]
Sculpting organism shape requires that cells produce forces with proper directionality. Thus, it is critical to understand how cells orient the cytoskeleton to produce forces that deform tissues. During Drosophila gastrulation, actomyosin contraction in ventral cells generates a long, narrow epithelial furrow, termed the ventral furrow, in which actomyosin fibres and tension are directed along the length of the furrow. Using a combination of genetic and mechanical perturbations that alter tissue shape, we demonstrate that geometrical and mechanical constraints act as cues to orient the cytoskeleton and tension during ventral furrow formation. We developed an in silico model of two-dimensional actomyosin meshwork contraction, demonstrating that actomyosin meshworks exhibit an inherent force orienting mechanism in response to mechanical constraints. Together, our in vivo and in silico data provide a framework for understanding how cells orient force generation, establishing a role for geometrical and mechanical patterning of force production in tissues.
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