期刊
CHEMICAL COMMUNICATIONS
卷 53, 期 62, 页码 8739-8742出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc04535b
关键词
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资金
- Fudan University
- National Natural Science Foundation of China [51503042, 21672042]
An acyclic cucurbit[n]uril (CB[n]) conjugated dextran is developed as a new biomaterial for drug delivery and bioimaging. This biomaterial retains the host-guest recognition properties of acyclic CB[n]s. It is able to directly encapsulate anti-tumor drugs 5-fluorouracil and temozolomide. This polymeric material can form a supramolecular assembly with polyethyleneimine (PEI). Although there is no conventional chromophore in these supramolecular systems, they exhibit aggregation-induced emission (AIE) in water with a quantum yield of 10%. This supramolecular assembly is used for bioimaging in vitro with good biocompatibility.
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