相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Sudemycin K: A Synthetic Antitumor Splicing Inhibitor Variant with Improved Activity and Versatile Chemistry
Kamil Makowski et al.
ACS CHEMICAL BIOLOGY (2017)
Global analysis of pre-mRNA subcellular localization following splicing inhibition by spliceostatin A
Rei Yoshimoto et al.
RNA (2017)
Large-scale analysis of branchpoint usage across species and cell lines
Allison J. Taggart et al.
GENOME RESEARCH (2017)
A central role of Cwc25 in spliceosome dynamics during the catalytic phase of pre-mRNA splicing
Chi-Kang Tseng et al.
RNA (2017)
Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome
Cara Lunn Shirai et al.
NATURE COMMUNICATIONS (2017)
Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability
Brenton R. Paolella et al.
ELIFE (2017)
The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mc1-1
M. Larrayoz et al.
LEUKEMIA (2016)
RNA mis-splicing in disease
Marina M. Scotti et al.
NATURE REVIEWS GENETICS (2016)
Selectivity in Small Molecule Splicing Modulation
Deepak Kumar et al.
ACS CHEMICAL BIOLOGY (2016)
Physiologic Expression of Sf3b1K700E Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation
Esther A. Obeng et al.
CANCER CELL (2016)
SF3B1/Hsh155 HEAT motif mutations affect interaction with the spliceosomal ATPase Prp5, resulting in altered branch site selectivity in pre-mRNA splicing
Qing Tang et al.
GENES & DEVELOPMENT (2016)
Dynamic Histone Acetylation of H3K4me3 Nucleosome Regulates MCL1 Pre-mRNA Splicing
Dilshad H. Khan et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2016)
The Spliceosomal Protein SF3B5 is a Novel Component of Drosophila SAGA that Functions in Gene Expression Independent of Splicing
Rachel Stegeman et al.
JOURNAL OF MOLECULAR BIOLOGY (2016)
Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations
Constantin Cretu et al.
MOLECULAR CELL (2016)
Splicing solutions: Companies explore new techniques to fix splicing errors
Shraddha Chakradhar
NATURE MEDICINE (2016)
Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins
Stanley Chun-Wei Lee et al.
NATURE MEDICINE (2016)
Therapeutic targeting of splicing in cancer
Stanley Chun-Wei Lee et al.
NATURE MEDICINE (2016)
Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages
Kerstin A. Effenberger et al.
RNA (2016)
Molecular architecture of the Saccharomyces cerevisiae activated spliceosome
Reinhard Rauhut et al.
SCIENCE (2016)
Structure of a yeast activated spliceosome at 3.5 Å resolution
Chuangye Yan et al.
SCIENCE (2016)
The Spliceosome: The Ultimate RNA Chaperone anc Sculptor
Panagiotis Papasaikas et al.
TRENDS IN BIOCHEMICAL SCIENCES (2016)
Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage
Samar Alsafadi et al.
NATURE COMMUNICATIONS (2016)
RNA splicing factors as oncoproteins and tumour suppressors
Heidi Dvinge et al.
NATURE REVIEWS CANCER (2016)
SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition
Eunhee Kim et al.
CANCER CELL (2015)
Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo
Cara Lunn Shirai et al.
CANCER CELL (2015)
Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing
Takayuki Nojima et al.
CELL (2015)
The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches
Elisabeth Daguenet et al.
EMBO REPORTS (2015)
Genome-wide discovery of human splicing branchpoints
Tim R. Mercer et al.
GENOME RESEARCH (2015)
Functional Splicing Network Reveals Extensive Regulatory Potential of the Core Spliceosomal Machinery
Panagiotis Papasaikas et al.
MOLECULAR CELL (2015)
The spliceosome is a therapeutic vulnerability in MYC-driven cancer
Tiffany Y. -T. Hsu et al.
NATURE (2015)
SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice
James Palacino et al.
NATURE CHEMICAL BIOLOGY (2015)
Splicing inhibition decreases phosphorylation level of Ser2 in Pol II CTD
Mitsunori Koga et al.
NUCLEIC ACIDS RESEARCH (2015)
Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point
Rachel B. Darman et al.
CELL REPORTS (2015)
SF3B1 Association with Chromatin Determines Splicing Outcomes
Nir Kfir et al.
CELL REPORTS (2015)
Widespread intron retention in mammals functionally tunes transcriptomes
Ulrich Braunschweig et al.
GENOME RESEARCH (2014)
Use of Bru-Seq and BruChase-Seq for genome-wide assessment of the synthesis and stability of RNA
Michelle T. Paulsen et al.
METHODS (2014)
RNA-dependent dynamic histone acetylation regulates MCL1 alternative splicing
Dilshad H. Khan et al.
NUCLEIC ACIDS RESEARCH (2014)
Sudemycin E influences alternative splicing and changes chromatin modifications
Paolo Convertini et al.
NUCLEIC ACIDS RESEARCH (2014)
U2 snRNP Is Required for Expression of the 3′ End of Genes
Mitsunori Koga et al.
PLOS ONE (2014)
SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy
Nikolai A. Naryshkin et al.
SCIENCE (2014)
Chemical Perturbation of Mcl-1 Pre-mRNA Splicing to Induce Apoptosis in Cancer Cells
Yang Gao et al.
ACS CHEMICAL BIOLOGY (2013)
Dynamic Integration of Splicing within Gene Regulatory Pathways
Ulrich Braunschweig et al.
CELL (2013)
Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A
Christopher G. Hubert et al.
GENES & DEVELOPMENT (2013)
Alternative splicing: a pivotal step between eukaryotic transcription and translation
Alberto R. Kornblihtt et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
The spliceosome as a target of novel antitumour drugs
Sophie Bonnal et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion
Cyrille Girard et al.
NATURE COMMUNICATIONS (2012)
Differential GC Content between Exons and Introns Establishes Distinct Strategies of Splice-Site Recognition
Maayan Amit et al.
CELL REPORTS (2012)
Sudemycins, Novel Small Molecule Analogues of FR901464, Induce Alternative Gene Splicing
Liying Fan et al.
ACS CHEMICAL BIOLOGY (2011)
Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A
Anna Corrionero et al.
GENES & DEVELOPMENT (2011)
The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region
Eric G. Folco et al.
GENES & DEVELOPMENT (2011)
Spliceosome assembly is coupled to RNA polymerase II dynamics at the 3′ end of human genes
Sandra Bento Martins et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Analysis of in situ pre-mRNA targets of human splicing factor SF1 reveals a function in alternative splicing
Margherita Corioni et al.
NUCLEIC ACIDS RESEARCH (2011)
Pre-mRNA splicing is a determinant of histone H3K36 methylation
Soojin Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
MCL-1V, a novel mouse antiapoptotic MCL-1 variant, generated by RNA splicing at a non-canonical splicing pair
Shogo Kojima et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Invariant U2 snRNA Nucleotides Form a Stem Loop to Recognize the Intron Early in Splicing
Rhonda Perriman et al.
MOLECULAR CELL (2010)
U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation
Daisuke Kaida et al.
NATURE (2010)
Characterization of purified human B act spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis
Sergey Bessonov et al.
RNA (2010)
Genome-Wide Association between Branch Point Properties and Alternative Splicing
Andre Corvelo et al.
PLOS COMPUTATIONAL BIOLOGY (2010)
The Spliceosome: Design Principles of a Dynamic RNP Machine
Markus C. Wahl et al.
CELL (2009)
Nucleosomes are well positioned in exons and carry characteristic histone modifications
Robin Andersson et al.
GENOME RESEARCH (2009)
Nucleosome positioning as a determinant of exon recognition
Hagen Tilgner et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Chromatin organization marks exon-intron structure
Schraga Schwartz et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Antitumor compounds based on a natural product consensus pharmacophore
Chandraiah Lagisetti et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
The splicing factor SC35 has an active role in transcriptional elongation
Shengrong Lin et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Human branch point consensus sequence is yUnAy
Kaiping Gao et al.
NUCLEIC ACIDS RESEARCH (2008)
Splicing factor SF3b as a target of the antitumor natural product pladienolide
Yoshihiko Kotake et al.
NATURE CHEMICAL BIOLOGY (2007)
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA
Daisuke Kaida et al.
NATURE CHEMICAL BIOLOGY (2007)
SAP155 binds to ceramide-responsive RNA cis-element 1 and regulates the alternative 5′ splice site selection of Bcl-x pre-mRNA
Autumn Massiello et al.
FASEB JOURNAL (2006)
A spliceosomal intron binding protein, IBP160, links position-dependent assembly of intron-encoded box C/D snoRNP to pre-mRNA splicing
Tetsuro Hirose et al.
MOLECULAR CELL (2006)
Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1
K Isono et al.
GENES & DEVELOPMENT (2005)
Molecular architecture of the multiprotein splicing factor SF3b
MM Golas et al.
SCIENCE (2003)
Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo
E Martinez et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
分享论文
