期刊
BIOESSAYS
卷 39, 期 8, 页码 -出版社
WILEY
DOI: 10.1002/bies.201700070
关键词
cryo-electron microscopy; DNA polymerases; DNA replication; initiation of replication; replisome
资金
- Intramural NIH HHS [Z01 ES065070-18] Funding Source: Medline
- NIGMS NIH HHS [R35 GM118129] Funding Source: Medline
Biochemical and cryo-electron microscopy studies have just been published revealing interactions among proteins of the yeast replisome that are important for highly coordinated synthesis of the two DNA strands of the nuclear genome. These studies reveal key interactions important for arranging DNA polymerases alpha, delta, and epsilon for leading and lagging strand replication. The CMG (Mcm2-7, Cdc45, GINS) helicase is central to this interaction network. These are but the latest examples of elegant studies performed in the recent past that lead to a much better understanding of how the eukaryotic replication fork achieves efficient DNA replication that is accurate enough to prevent diseases yet allows evolution.
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